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Dehydroepiandrosterone (DHEA): Uses, side effects, and interactions
We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission. Dehydroepiandrosterone, better known as DHEA, is a steroid hormone. It is naturally synthesized by the body and performs a number of roles. It has been investigated widely for its possible therapeutic effects in a range of conditions. The human body naturally makes DHEA. It can convert into a range of hormones, including androgens and estrogens, the male and female sex hormones.
DHEA is also available in supplements, made synthetically using chemicals found in soy and wild yam. However, consuming wild yam or soy will not enable the human body to make more DHEA. DHEA supplements claim to help with a range of conditions, including sexual dysfunction, lupusdepressionadrenal insufficiency, cervical cancervaginal atrophyand weight loss. Some research supports its use.
In addition, the quality of products on sale is not always consistent. DHEA is an endogenous steroid hormone. This means it is naturally made by the body, and it spurs specific tissues or cells into action.
DHEA is one of the most abundant steroid hormones in the human body. It is produced by the adrenal glands, the gonads, and the brain. It is important for creating estrogen and androgen sex hormones and contributes to the development of so-called androgenic effects, or masculinization. These changes include the production of oilier skin, changes in body odorand the growth of armpit and pubic hair.
DHEA may also have other roles, for example, as a neurosteroid. In this role, it would directly affect neuronal excitability. Some say that DHEA enhances athletic performance. Production of DHEA peaks when people are in their 20s and 30sand then it declines. This is the main reason that DHEA is considered an important chemical in the aging process, and a potential target for anti-aging drugs. Wild yam and soy contain chemicals that can be converted into DHEA in a laboratory.
However, the body cannot convert them in the same way. Eating soy or yams will not increase DHEA levels. Research into DHEA has increased in recent years, but many questions remain about its effectiveness and possible adverse effects. Its activities are not fully understood, but some researchers believe it helps protect neurons from toxins and after injuries, such as strokes.
Some research suggests that it may contribute to nerve growth, and that it may help reduce inflammation and prevent cell death. It may also modulate mood. For this reason, it has been studied for the treatment of mood disorders, such as anxiety and depression.
Research published in the journal Nature in found that DHEA enhanced connections between the amygdala and hippocampus and reduced activity levels in both regions. These changes are thought to contribute to an enhanced mood and a reduced memory for emotional events. There are also concerns that DHEA can trigger mania, psychosisand other mood changes, especially in people with bipolar disorder and other mental health issues.
DHEA is not recommended for use alongside various drugs, including antidepressantsmood stablizers, and anti-seizure drugs. Under caloric restriction, for example, DHEA quantities increase.
For this reason, some have suggested that caloric restriction might increase lifespan. Over the last decade, DHEA has been studied for its effectiveness in treating a number of diseases and conditions.
Success rates have varied. Some diseases cause a reduction in bone density. Some research suggests that artificially raising DHEA levels helps increase bone density, especially in women. However, not all studies have produced positive results.
Depression has been linked to low blood levels of DHEA. There is evidence that DHEA could help relieve symptoms of depression. A review of research, published insuggested that DHEA might improve symptoms of depression in people with schizophreniaanorexia nervosaHIVand adrenal insufficiency. Some evidence suggests that DHEA may help reduce weight in older patients with metabolic conditions. This can only happen, however, if the body can convert the DHEA in the supplements into androgens or estrogens.
The effect on younger people with excess weight is not known. A small study of 26 people with anorexia nervosa found that those who took milligrams mg of DHEA supplements for 6 months saw an increase in body mass index BMI and also enhancements in mood. Supplementing with DHEA can reduce symptoms of adrenal insufficiency, but side effects can be substantial.
Further evidence is needed to confirm its effectiveness overall. This is an autoimmune disorder affecting the skin and organs. DHEA levels are lower than normal in women with lupus. Some research shows that DHEA improves a number of lupus symptoms. Some studies suggest DHEA may help people with deficits in sexual function, libido, and erectile dysfunction. However, other results have been inconclusive. The effect appears to be more significant in women who have undergone menopause.
Evidence that DHEA supplements could help stave off age-related changes is weak or unproven. Some studies have suggested that DHEA might help prevent replication of the HIV virus and bolster the immune system, but the authors of at least one study, published infound that it did not have these effects.
The researchers did not recommend using it routinely as an additional therapy for people with HIV. Results of laboratory investigations suggest that DHEA may inhibit the proliferation of cervical cancer cells, and that it could protect against the migration of cancer cells. In older people, there is a small amount of weak evidence that supports this type of effect. Most studies, especially in adults, have found little or no effect. DHEA is widely available to purchase over-the-counter, but there is scant evidence to support its safety or effectiveness.
Many sources advise against using DHEA, especially without first seeking medical advice, because of the possible side effects. DHEA affects the endocrine system, which means it affects hormonal activity. Hormonal changes can impact on a range of body systems. As a result, a wide variety of side effects are possible.
In addition, DHEA has not been tested or widely used over a long period of time, so it is not clear what the long-term effects might be. Because 7-keto-DHEA is not converted to steroid hormones by the body, the risk of some of the hormonal side effects is reduced. Although 7-keto-DHEA has been promoted as assisting in weight-loss, building muscle and stimulating the immune system, evidence supporting any of these claims is limited.
Medications often interact with each other. DHEA has a complex role, and a range of interactions can occur when using it with other medications. Special caution is needed when using DHEA alongside any of the following drugs or substances:.
DHEA must be avoided with testosterone therapy, as it can lead to a low sperm count and enlarged breasts in men and in male characteristics in women. People with the following risks or conditions should be especially careful when considering DHEA:. DHEA supplements should not be taken during pregnancy or while breastfeeding. Children should not use it. DHEA is a complicated chemical with many roles.
In the future, it may be used in a variety of treatment. For now, however, it is best to be cautious when using it, as there is a lack of evidence regarding its safety and effectiveness. A range of DHEA supplements are available for purchase online. Phytoestrogens are a natural compound found in plants. When eaten, they may affect a person in the same way as estrogen produced by the body. Meldonium is perhaps most well-known for its role in sports doping.
This article will explore the story of its origin and its broad medical uses in…. Testosterone is a sex hormone that regulates sexual development, muscle mass, and red blood cell production. It originates mainly in the testicles and…. Many athletes turn to caffeine as a way of boosting their performance, but a new study suggests that regular caffeine intake may have the opposite….
The amazing story of hepatitis C, from discovery to cure New directions in dementia research Can psychedelics rewire a depressed, anxious brain? Medical News Today.
Health Conditions Discover Tools Connect. How can DHEA benefit your health? Medically reviewed by Alan Carter, Pharm. What is DHEA? Naturally raising levels Medical use Side effects Drug interactions Risks We include products we think are useful for our readers.
Its role is not fully understood, but it plays an important part in the synthensizing estrogen and androgen. Eating yams and soy does not increase DHEA in the body. DHEA has been tested for use in many diseases, including depression, osteoporosisand lupus, but there is little evidence to confirm its benefits.
❿- Dhea prednisone
Dhea prednisone.
Skip to main content. Search SpringerLink Search. Summary A dysfunction of the hypothalamic — pituitary — adrenal HPA axis was found in animal models of chronic inflammatory diseases, and the defect was located in more central portions of the HPA axis.
Straub, J. Zietz Authors R. Straub View author publications. View author publications. Rights and permissions Reprints and Permissions. About this article. Hormonal changes can impact on a range of body systems. As a result, a wide variety of side effects are possible. In addition, DHEA has not been tested or widely used over a long period of time, so it is not clear what the long-term effects might be.
Because 7-keto-DHEA is not converted to steroid hormones by the body, the risk of some of the hormonal side effects is reduced. Although 7-keto-DHEA has been promoted as assisting in weight-loss, building muscle and stimulating the immune system, evidence supporting any of these claims is limited.
Medications often interact with each other. DHEA has a complex role, and a range of interactions can occur when using it with other medications.
Special caution is needed when using DHEA alongside any of the following drugs or substances:. DHEA must be avoided with testosterone therapy, as it can lead to a low sperm count and enlarged breasts in men and in male characteristics in women.
People with the following risks or conditions should be especially careful when considering DHEA:. DHEA supplements should not be taken during pregnancy or while breastfeeding. Children should not use it. DHEA is a complicated chemical with many roles.
In the future, it may be used in a variety of treatment. For now, however, it is best to be cautious when using it, as there is a lack of evidence regarding its safety and effectiveness. A range of DHEA supplements are available for purchase online. Phytoestrogens are a natural compound found in plants. When eaten, they may affect a person in the same way as estrogen produced by the body. Meldonium is perhaps most well-known for its role in sports doping.
This article will explore the story of its origin and its broad medical uses in…. Testosterone is a sex hormone that regulates sexual development, muscle mass, and red blood cell production. It originates mainly in the testicles and…. Many athletes turn to caffeine as a way of boosting their performance, but a new study suggests that regular caffeine intake may have the opposite…. The amazing story of hepatitis C, from discovery to cure New directions in dementia research Can psychedelics rewire a depressed, anxious brain?
Medical News Today. Health Conditions Discover Tools Connect. How can DHEA benefit your health? Medically reviewed by Alan Carter, Pharm. What is DHEA? Naturally raising levels Medical use Side effects Drug interactions Risks We include products we think are useful for our readers. Its role is not fully understood, but it plays an important part in the synthensizing estrogen and androgen.
Eating yams and soy does not increase DHEA in the body. Since in these patients, administration of prednisolone or the chronic inflammatory process itself alters adrenal function, endogenous adrenal hormones in relation to proinflammatory cytokines change. Furthermore, these mechanisms may also lead to shifts in steroidogenesis which have been demonstrated in chronic inflammatory diseases.
Since DHEAS is the pool for peripheral sex steroids, such as testosterone and 17 beta-estradiol, lack of this hormone leads to a significant sex hormone deficiency in the periphery. On further follow up, she reported significant improvement in her energy levels and performance. She also managed to wean her Prednisolone from 5mg to 3mg and returned to work, active as before.
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences. Searchable abstracts of presentations at key conferences in endocrinology. Endocrine Abstracts.
We present here a case of 70 year old female, seen in endocrine clinic for Hypothalamic-Pituitary-Adrenal HPA axis suppression after prolonged glucocorticoid use. History revealed that she had prolonged use of prednisolone for her asthma in the past. InPrednisolone was stopped but she had to be started on Hydrocortisone replacement due to HPA axis suppression.
She was taking Hydrocortisone 20 mg BD. Trials to wean her off Hydrocortisone failed due to ongoing tiredness and dizziness. She, generally, had very low energy levels and was struggling with daily activities.
She had to quit her demanding job as an Event Manager. There was no other confounding medical history. Other investigations for tiredness including pituitary profile, TFT, haematinics and bone profile were normal. Several attempts were made to decrease her hydrocortisone dose but she failed to cope with any reductions. In Octobershe was switched to Prednisolone 5 mg OD, as a trial therapy, but no improvement in her symptoms was observed.
On further follow up, she reported significant improvement in her energy levels and performance. She also managed to wean her Prednisolone from 5mg to 3mg and returned to work, active as before. Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences. Searchable abstracts of presentations at key conferences in endocrinology.
Endocrine Abstracts. Prev Next. Volume 55 Prev. Article tools. My recent searches. My recently viewed abstracts. DHEA: is it fountain of youth or medical need? BiosciAbstracts Biosci Abstracts.
Basal serum DHEA and DHEAS concentrations were suppressed to a greater degree than was cortisol during both daily and alternate day prednisone treatments. No interactions were found between DHEA and prednisone. However, this does not necessarily mean no interactions exist. Always consult your healthcare. Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammatory diseases – substitutes of adrenal and sex hormones. In , Prednisolone was stopped but she had to be started on Hydrocortisone replacement due to HPA axis suppression. She was taking Hydrocortisone 20 mg BD. Dehydroepiandrosterone (DHEA) is a naturally occurring steroid hormone that, to date, is not well-understood. It is classed as a performance-enhancing drug. However, other results have been inconclusive. Straub View author publications. History revealed that she had prolonged use of prednisolone for her asthma in the past. DHEA is a complicated chemical with many roles. BiosciAbstracts Biosci Abstracts.A dysfunction of the hypothalamic-pituitary-adrenal HPA axis was found in animal models of chronic inflammatory diseases, and the defect was located in more central portions of the HPA axis. This defect of neuroendocrine regulatory mechanisms contributes to the onset of the model disease. Since these first observations in animal models were made, evidence has accumulated that the possible defect in the HPA axis in humans is more distal to the hypothalamus or pituitary gland: In chronic inflammatory diseases, such as rheumatoid arthritis, an alteration of the HPA stress response results in inappropriately low cortisol secretion in relation to adrenocorticotropic hormone ACTH secretion.
Furthermore, it has recently been shown that the serum levels of another adrenal hormone, dehydroepiandrosterone DHEA , were significantly lower after ACTH stimulation in patients with rheumatoid arthritis without prior corticosteroids than in healthy controls.
These studies clearly indicate that chronic inflammation alters, particularly, the adrenal response. However, at this point, the reason for the specific alteration of adrenal function in relation to pituitary function remains to be determined. Since one of the down-regulated adrenal hormones, DHEA, is an inhibitor of cytokines due to an inhibition of nuclear factor-kappa B NF-kappa B activation, low levels of this hormone may be deleterious in chronic inflammatory diseases.
Since IL-6 is an important factor for B lymphocyte differentiation, the missing down-regulation of this cytokine, and others such as TNF, may be a significant risk factor in rheumatic diseases. Since in these patients, administration of prednisolone or the chronic inflammatory process itself alters adrenal function, endogenous adrenal hormones in relation to proinflammatory cytokines change. Furthermore, these mechanisms may also lead to shifts in steroidogenesis which have been demonstrated in chronic inflammatory diseases.
Since DHEAS is the pool for peripheral sex steroids, such as testosterone and 17 beta-estradiol, lack of this hormone leads to a significant sex hormone deficiency in the periphery. As a consequence, we suggest a combined therapy with corticosteroids plus DHEA in chronic inflammatory diseases.
Abstract A dysfunction of the hypothalamic-pituitary-adrenal HPA axis was found in animal models of chronic inflammatory diseases, and the defect was located in more central portions of the HPA axis.
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